Catalytic oxidation of hydroxyurea to bound NO+/NO2 mediated by pentacyano(L)ferrates. Characterization of the nitroxide radical, bound C-nitrosoformamide and NO as reaction intermediates - Academic Article uri icon

Resumen

  • Hydroxyurea (HU, NH2CONHOH), reacts with several oxidizing agents (O2, H2O2, IO4-, Fe(III) complexes) in aqueous solutions containing either of the pentacyano(aqua)ferrate(II,III) ions, [FeII,III(CN)5H2O]3,2−. In the initial 1-electron step, HU reacts with [FeIII(CN)5H2O]2− through an outer-sphere process, leading to [FeII(CN)5H2O]3− and the EPR active nitroxide radical, NH2C(O)NHO. This is further oxidized to C-nitrosoformamide, NH2C(O)NO, in a similar 1-electron step.

Fecha de publicación

  • 2011