White rot produced by Sclerotium cepivorum is the main limitation to garlic production in Colombia causing losses that exceed 50%. The absence of quality seed contributes to its dissemination and infestation in sowing areas, the main control strategy is the application of fungicides; therefore, it is necessary to integrate management alternatives that promote its sustainability. Thus, the objective of this study was to determine under controlled conditions the potential of control for S. cepivorum with microbial antagonists and essential oils. The effect on the pathogen’s growth was determined in PDA supplemented with each oil and for the antagonists its ability to degrade sclerotia. In soil infested with sclerotia was determined the effect on incidence and mortality reduction with the applications of the antagonists and selected oils. The results showed that exposure to eucaliptus (10,000 ppm) and oregano (200; 250 ppm) oils inhibited by 92% growth of the pathogen, while antagonists colonized more than 95% of sclerotia, causing their degradation. While in infested soil they showed a control between 30 and 70%, being Trichoderma asperellum Th034 which presented the lowest incidence and mortality (21%).